Clinical Trials for Patients with Peripheral Vascular Disease

Study Title: REVIVE Study

Study Description: This study is for patients who have been diagnosed with
peripheral vascular disease and have severe leg pain and non-healing ulcers.
 
Principal Investigator: Emerson C. Perin, MD, PhD

The Stem Cell Center of the Texas Heart Institute at St. Luke’s Episcopal Hospital in Houston, Texas is actively recruiting patients for an FDA-approved clinical study investigating the use of stem cells or gene therapy in aiding with recovery in cases of peripheral vascular disease.

Peripheral vascular disease results from blockages in arteries that feed the muscles and tissues of the legs. If there are severe blockages, patients may develop severe pain in their leg muscles when walking (claudication), and at rest. Lack of or no blood flow to the legs can lead to non-healing wounds, ulceration, and limb loss.

The Stem Cell Center is now investigating the effects of injecting bone marrow derived stem cells or gene therapy directly into the leg muscles in legs affected by blocked arteries. 

Inclusion Criteria

The Stem Cell Center is actively recruiting patients:

• with severe leg pain from blocked arteries in the legs (claudication).
• with evidence of blockage using non-invasive testing (i.e. ABI) .
• withblockages not amenable to conventional therapy including bypass or angioplasty.
• with no active infection in the affected leg.
• with ulcerations on the effected leg.

Many factors are considered before enrolling patients into a research study and enrollment varies according to inclusion criteria.

Enrollment Information

If you are a Patient and wish to be considered for enrollment in a PVD trial, please call us toll free at 1-866-924-STEM (7836) or complete our secure online Patient Information Form. 

If you are a Physician and would like to refer a patient for consideration, please contact a study coordinator at 832-355-9405.

Updated November 2012