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Electrophysiology Clinical Research & Innovations
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Mission Statement

The mission of the Electrophysiology Clinical Research & Innovations program (ECRI) is to create and develop an infrastructure for translational and clinical cardiac arrhythmia research and innovation in order to establish Texas Heart Institute as a nationally and internationally recognized leader in the field of cardiac arrhythmias.

Projects

ECRI is focused on design and implementation of ongoing research projects targeting detection, management, and treatment of cardiac arrhythmias and the development of strategies for community-wide cardiovascular disease education.

Ongoing studies include a variety of clinical research topics, as follows:

  • Study of the effects of weight loss supplements on heart rhythm;
  • Identification of important risk factors for development of specific cardiac rhythm disorders (atrial fibrillation) during and after cardiac surgery;
  • Evaluation of a predictive scoring system and possible interventions to mitigate these risks.
EPCI also performs numerous translational and large animal studies to test new drugs, procedures or devices for treatment or prevention of heart rhythm disorders and ECRI investigators developed the first electrophysiology database for Texas Heart Institute.   

Definitions  

Electrophysiology: The biomedical field dealing with the study of electric activity in the body, including that of the heart.

Arrhythmia: Any irregularity in the heart's natural rhythm 

Atrial fibrillation: An abnormal and irregular heart rhythm in which electrical signals are generated chaotically throughout the upper chambers (atria) of the heart.
 

Department Staff

Mehdi Razavi, MD – Director 

Recent Publications

Ho, S.C., M. Razavi, A. Nazeri, and G. Song, FBG sensor for contact level monitoring and prediction of perforation in cardiac ablation. Sensors (Basel), 2012. 12(1): p. 1002-13.

Saeed, M., M. Razavi, C.G. Neason, and S. Petrutiu, Rationale and design for programming implantable cardioverter-defibrillators in patients with primary prevention indication to prolong time to first shock (PROVIDE) study. Europace, 2011. 13(11): p. 1648-52. 

Ganjehei, L., M. Razavi, and A. Rasekh, Catheter-based ablation of atrial fibrillation: a brief overview. Tex Heart Inst J, 2011. 38(4): p. 361-3. 

Ganjehei, L., A. Massumi, M. Razavi, and A. Rasekh, Stroke prevention in nonvalvular atrial fibrillation. Tex Heart Inst J, 2011. 38(4): p. 350-2. 

Ganjehei, L., A. Massumi, A. Nazeri, and M. Razavi, Cardiac arrhythmias in women. Tex Heart Inst J, 2011. 38(2): p. 157-9. 

Ganjehei, L., A. Massumi, A. Nazeri, and M. Razavi, Pharmacologic management of arrhythmias. Tex Heart Inst J, 2011. 38(4): p. 344-9. 

Eifling, M., M. Razavi, and A. Massumi, The evaluation and management of electrical storm. Tex Heart Inst J, 2011. 38(2): p. 111-21. 

Saeed, M., C.G. Neason, M. Razavi, S. Chandiramani, J. Alonso, S. Natarajan, J.H. Ip, D.F. Peress, S. Ramadas, and A. Massumi, Programming antitachycardia pacing for primary prevention in patients with implantable cardioverter defibrillators: results from the PROVE trial. J Cardiovasc Electrophysiol, 2010. 21(12): p. 1349-54. 

Nazeri, A., M. Razavi, M.A. Elayda, V.V. Lee, A. Massumi, and J.M. Wilson, Race/ethnicity and the incidence of new-onset atrial fibrillation after isolated coronary artery bypass surgery. Heart Rhythm, 2010. 7(10): p. 1458-63. 

Colombowala, I.K., A. Massumi, A. Rasekh, M. Saeed, J. Cheng, B. Fakhri, M. Shuraih, and M. Razavi, Variability in postpacing intervals predicts global ventricular activation pattern during tachycardia. Pacing Clin Electrophysiol, 2010. 33(2): p. 129-34. 

Bensler, J.M., C.M. Frank, M. Razavi, A. Rasekh, M. Saeed, P.C. Haas, A. Nazeri, and A. Massumi, Tachycardia-mediated cardiomyopathy and the permanent form of junctional reciprocating tachycardia. Tex Heart Inst J, 2010. 37(6): p. 695-8. 

Nazeri, A., A. Rasekh, A. Massumi, and M. Razavi, Coalescence of splines on a basket mapping catheter during ablation using a closed-loop irrigation catheter. Europace, 2009. 11(2): p. 258-9. 

Nazeri, A., A. Massumi, J.M. Wilson, C.M. Frank, M. Bensler, J. Cheng, M. Saeed, A. Rasekh, and M. Razavi, Arrhythmogenicity of weight-loss supplements marketed on the Internet. Heart Rhythm, 2009. 6(5): p. 658-62. 

Frank, C.M., M. Razavi, M. Saeed, R.C. Bogaev, and A. Massumi, Recognition and management of complex rhythm disorders in heterotopic heart transplantation. J Heart Lung Transplant, 2009. 28(3): p. 294-6. 

Virani, S.S., V. Nambi, M. Razavi, V.V. Lee, M. Elayda, J.M. Wilson, and C.M. Ballantyne, Preoperative statin therapy is not associated with a decrease in the incidence of postoperative atrial fibrillation in patients undergoing cardiac surgery. Am Heart J, 2008. 155(3): p. 541-6.

Massumi, A., A. Rasekh, M. Saeed, S. Flam, B. Cheong, H. Mojibian, and M. Razavi, Organized incessant atrial arrhythmias in the setting of severe, isolated biatrial scarring. Pacing Clin Electrophysiol, 2008. 31(6): p. 666-75. 

Colombowala, I.K., A. Massumi, A. Rasekh, M. Saeed, J. Cheng, B. Fakhri, M. Shuraih, and M. Razavi, Variability in post-pacing intervals predicts global atrial activation pattern during tachycardia. J Cardiovasc Electrophysiol, 2008. 19(2): p. 142-7. 

Shuraih, M., T. Ai, M. Vatta, Y. Sohma, E.M. Merkle, E. Taylor, Z. Li, Y. Xi, M. Razavi, J.A. Towbin, and J. Cheng, A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents. J Cardiovasc Electrophysiol, 2007. 18(4): p. 434-40. 

Nader, A., A. Massumi, J. Cheng, and M. Razavi, Inherited arrhythmic disorders: long QT and Brugada syndromes. Tex Heart Inst J, 2007. 34(1): p. 67-75.  

Kohsaka, S., M. Razavi, and A. Massumi, Idiopathic ventricular fibrillation successfully terminated by radiofrequency ablation of the distal Purkinje fibers. Pacing Clin Electrophysiol, 2007. 30(5): p. 701-4.  

Razavi, M., S. Zhang, S. Delapasse, D. Yang, T. Ai, B. Kar, G. Younis, A. Rasekh, and J. Cheng, The effects of pulmonary vein isolation on the dominant frequency and organization of coronary sinus electrical activity during permanent atrial fibrillation. Pacing Clin Electrophysiol, 2006. 29(11): p. 1201-8. 

Razavi, M., J. Cheng, A. Rasekh, D. Yang, S. Delapasse, T. Ai, T. Meade, A. Donsky, M.J. Goodman, and A. Massumi, Slow pathway ablation decreases vulnerability to pacing-induced atrial fibrillation: Possible role of vagal denervation. Pacing Clin Electrophysiol, 2006. 29(11): p. 1234-9. 

Razavi, M., S. Zhang, D. Yang, R.A. Sanders, B. Kar, S. Delapasse, T. Ai, W. Moreira, B. Olivier, D.S. Khoury, and J. Cheng, Effects of pulmonary vein ablation on regional atrial vagal innervation and vulnerability to atrial fibrillation in dogs. J Cardiovasc Electrophysiol, 2005. 16(8): p. 879-84. 

Razavi, M., D.M. Luria, A. Jahangir, D.O. Hodge, P.A. Low, and W.K. Shen, Acute blood pressure changes after the onset of atrioventricular nodal reentrant tachycardia: a time-course analysis. J Cardiovasc Electrophysiol, 2005. 16(10): p. 1037-40. 

Razavi, M., Safe and effective pharmacologic management of arrhythmias. Tex Heart Inst J, 2005. 32(2): p. 209-11.
 

Contact Information and Location

Electrophysiology Clinical Research & Innovations
 
Dr. Mehdi RazaviMehdi Razavi, MD — Director
6624 Fannin, Suite 2480
Houston, TX 77030 
713-529-5530; Fax 713-791-1786



Updated June 2013
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