Grand Rounds | 2024-2025

A Change of Heart: From Genetics of Heart Disease to New Therapeutics

Deepak Srivastava, MD, FAHA

President and Senior Investigator
Director, Roddenberry Stem Cell Center
Robert W. and Linda Mahley Distinguished Professorship
Gladstone Institutes
San Francisco, California

Wilma and Adeline Pirag Distinguished Professor in Pediatric Development Cardiology
Professor, Pediatrics and Biochemistry and Biophysics
University of California, San Francisco

Pediatric Cardiologist
UCSF Benioff Children’s Hospitals

Nonresident Scholar for Biomedical Research Policy
The Baker Institute for Public Policy
Rice University
Houston, Texas

Note: CME credits & MOC points will not be awarded for this presentation.

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Aortic Root Pathology: Where Are We?

Joseph S. Coselli, MD, FACS

Professor and Executive Vice Chair
Department of Surgery
Cullen Foundation Endowed Chair
Program Director, Aortic Surgery Fellowship
Baylor College of Medicine
St. Luke’s Health – Baylor St. Luke’s Medical Center

Academic Professional Staff
The Texas Heart Institute
Houston, Texas

Overview:

We will discuss the role of aortic root replacement and the challenges, including the use of TAVR.

Objectives:

At the conclusion of the activity a participant should be able to:

• Examine the circumstances and etiology of root degeneration.
• Review the basics of aortic root replacement.
• Identify the results of the various root surgical therapies.

Disclosures:

Joseph S. Coselli, MD, is a researcher, advisor, consultant, and speaker for, and receives honoraria and royalties from, Terumo Aortic. He is an investigator for Medtronic, W.L. Gore and Associates, Inc., and Artivion, Inc.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

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The Future of Cardiovascular Disease: Will Artificial Intelligence Replace Cardiologists and Vascular Specialists?

Tony S. Das, MD, FACC

Founder and CEO, Connected Cardiovascular Care Associates
Chief, Cardiovascular Strategic Planning and Development
Baylor Scott & White Health
Dallas, Texas

Overview:

Dr. Das will discuss the potential implications of Artificial Intelligence (AI) for the future diagnosis and treatment of cardiovascular disease.

Objectives:

At the conclusion of the activity a participant should be able to:

• Define terminology related to Artificial Intelligence.
• Evaluate new technologies for cardiovascular diagnosis and treatment from an AI standpoint.
• Discuss potential uses of AI for vascular specialists.

Disclosures:

Tony Das, MD, FACC, is a consultant for Arineta, Heartflow, and Elucid. He is a Board Member for Acarix.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CME credits must be claimed within 24 hours after a live conference.

Aortic Regurgitation: The Changing Landscape of Diagnosis & Management

William A. Zoghbi, MD, FASE, FAHA, MACC

Chair, Department of Cardiology
Houston Methodist DeBakey Cardiology Associates
Elkins Family Distinguished Chair in Cardiac Health
Houston Methodist DeBakey Heart & Vascular Center
Professor of Cardiology, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College
Houston, Texas

Overview:

Dr. Zoghbi will review the etiologies of aortic regurgitation, new developments in assessing regurgitation severity and adaptation of the heart, and the latest in management.

Objectives:

At the conclusion of the activity a participant should be able to:

• Review the incidence, various etiologies, and clinical manifestations of aortic regurgitation.
• Discuss criteria for aortic regurgitation severity with doppler echocardiography as well as cardiac MR and share the evolving changes in criteria of severity that impact the patient outcomes.
• Discuss current ACC/AHA guidelines of management of significant aortic regurgitation and the merging impact of cardiovascular imaging in modulating treatment strategies with surgical or percutaneous interventions.

Disclosures:

William A. Zoghbi, MD, has nothing to disclose relevant to this program.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

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A New Digital Era in Cardiovascular Interventions

Yiannis S. Chatzizisis, MD, PhD, FACC, FAHA, FSCAI, FESC

Chief, Division of Cardiovascular Medicine
Professor of Medicine
Director, Center for Digital Cardiovascular Innovations
University of Miami Health System
Leonard M. Miller School of Medicine
University of Miami
Miami, Florida

Overview:

Dr. Chatzizisis will introduce 21st century digital technologies and discuss the role of digital technologies in clinical decision making and pre-procedural planning. He will explain the role of digital technologies in device R&D and regulatory approval, as well as use of artificial intelligence and computational simulations in education and training.

Objectives:

At the conclusion of the activity a participant should be able to:

• Discuss the role of digital technologies in clinical decision making and pre-procedural planning.
• Describe the role of digital technologies in device R&D and regulatory approval.
• Discuss the use of artificial intelligence and computational simulations in education and training.

Disclosures:

Yiannis S. Chatzizisis, MD, PhD, is a consultant and received honoraria from Boston Scientific and Medtronic.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Carbon Nanotube Fibers Reduce Scar-Based Reentrant Arrhythmias

Mark McCauley, MD, PhD

Associate Professor of Medicine
Director, Electrophysiology Program
Department of Medicine, Division of Cardiology
University of Illinois College of Medicine
University of Illinois Chicago
University of Illinois Hospital
Jesse Brown VA Medical Center
Chicago, Illinois

Overview:

Carbon nanotube fibers (CNT) hold immense promise in restoring electrical conduction within the heart and reducing arrhythmias.

Objectives:

At the conclusion of the activity a participant should be able to:

• Describe the mechanisms of reentry in the heart.
• Describe how CNT fibers promote cardiac conduction within the heart.
• Apply CNT based conduction to reduce atrial and ventricular arrhythmias.

Disclosures:

Mark McCauley, MD, PhD, has nothing to disclose relevant to this program.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Clinical and Imaging Characteristics of Chagas Cardiomyopathy

Carlos Morillo, MD, FRCPC, FACC, FHRS, FESC

Professor, Department of Cardiac Sciences and Medicine
Section Chief, Cardiology Division
Libin Cardiovascular Institute of Alberta
Cummings School of Medicine
University of Calgary
Zone Head Cardiology
Calgary & Southeastern Alberta Region
Alberta Health Services
Calgary Alberta, Canada

Overview:

Chagas cardiomyopathy is caused by infection with Trypanosoma cruzi. Chagas has an acute and chronic stage that is associated with a rapidly progressive cardiomyopathy characterized by conduction disorders, ventricular tachycardia and refractory and progressive heart failure. Imaging can play a role in identifying subjects that will progress to cardiomyopathy and stratify risk of sudden cardiac death (SCD). The clinical presentation, management and role of imaging in Chagas cardiomyopathy will be reviewed in this presentation.

Objectives:

At the conclusion of the activity a participant should be able to:

• Determine the pathophysiology of Chagas disease and chronic Chagas cardiomyopathy.
• Describe the role of etiologic treatment in Chagas disease.
• Summarize the role of cardiac imaging (Echo and CMRI) in identifying patients that will progress to overt cardiomyopathy and risk stratify patients at risk of SCD.

Disclosures:

Carlos A. Morillo, MD, has nothing to disclose relevant to this program.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CME credits must be claimed within 24 hours after a live conference.

Multimodality Imaging of Pericardiac Diseases & Targeted Therapy

Allan L. Klein, MD, FRCP(C), FACC, FAHA, FASE, FESC

Professor of Medicine
Director, Center for the Diagnosis and Treatment of Pericardial Diseases
Director, Cardiovascular Imaging Research
Staff Cardiologist, Section of Cardiovascular Imaging
Robert and Suzanne Tomsich Department of Cardiovascular Medicine
Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute
Cleveland Clinic
Cleveland, Ohio

Overview:

Dr. Klein will discuss the new concepts and role of multimodality imaging in guiding therapy in pericarditis.

Objectives:

At the conclusion of the activity a participant should be able to:

• Discuss new concepts in pericardial disease.
• Describe the role of multimodality imaging in pericarditis.
• Discuss new therapeutics in recurrent pericarditis.

Disclosures:

Allan L. Klein, MD, received research grants from and is on the advisory boards for Kiniska Pharmaceuticals and Cardiol Therapeutics. He is also on the advisory board for Pfizer. Dr. Klein received royalties from Wolters Kluwer Elsevier.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Cloud-Based Monitoring and Rapid Response – Innovations and Outcomes

James Herlihy, MD

Professor of Medicine – Pulmonary
Baylor College of Medicine
Founding Chief, Critical Care Service
St. Luke’s Health – Baylor St. Luke’s Medical Center
Houston, Texas

Overview:

Up to 10% of patients on acute care hospital wards of hospitals experience an unexpected decompensation into critical illness. Dr. Herlihy will describe interventions used to identify and rescue these patients over the past 20 years. He will also review innovations in patient monitoring and response systems, as well as outcomes from such efforts at Baylor St. Luke’s Medical Center (BSLMC).

Objectives:

At the conclusion of the activity a participant should be able to:

• Identify the risk of unexpected decompensation for patients on acute care wards of hospitals.
• Describe the interventions currently in practice to prevent such decompensation (Rapid Response Systems (RRSS)) or rescue patients from these events.
• Describe innovations in rapid response developed and deployed at BSLMC, and future avenues of research in this field.

Disclosures:

James Herlihy, MD, is a founder and stockholder for Obvius Robotics.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CME credits must be claimed within 24 hours after a live conference.

Mitral and Aortic Valve Repair: When It Works and When It Does Not

Marc R. Moon, MD

Professor, Surgery
Chief, Division of Cardiothoracic Surgery
Baylor College of Medicine
Chief, Adult Cardiac Surgery Section
St. Luke’s Health – Baylor St. Luke’s Medical Center

Academic Professional Staff
Chief, Adult Cardiac Surgery
The Texas Heart Institute

Denton A. Cooley, MD Chair in Cardiac Surgery
St. Luke’s Foundation
Houston, Texas

Overview:

In this presentation, Dr. Moon will review the latest techniques for mitral and aortic valve repair and expected outcomes based on etiology and pathoanatomy of valvular disease. Specific technical challenges will be demonstrated including preoperative, intraoperative, and postoperative echocardiographic analysis. Focus will be on predicting success and identification of patients in whom long–term success following repair is guarded.

Objectives:

At the conclusion of the activity a participant should be able to:

• Determine pathoanatomy of mitral and aortic valve disease based on echocardiography and intraoperative valve assessment.
• Evaluate repair potential of left-sided valve disease based on etiology and lesions identified preoperatively.
• Summarize predicted outcomes of valve repair and determine when replacement may be a better option.

Disclosures:

Marc R. Moon, MD, is a consultant and on the advisory boards for Edwards and Medtronic.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Volumetric Analysis of Valvular Regurgitation – Why It Is Important

Hartzell V. Schaff, MD

Stuart W. Harrington Professor of Surgery
Consultant, The Department of Cardiovascular Surgery
Faculty Member, The Mayo Clinic Graduate School of Biomedical Sciences
Mayo Clinic
Rochester, Minnesota

Overview:

Dr. Schaff will review the importance of considering chamber volumes in assessing severity of valvular regurgitation. Volumetric analysis also helps in understanding the changes in ventricular geometry after correction of valve regurgitation as well as the impact of atrioventricular valve regurgitation in cardiomyopathy.

Objectives:

At the conclusion of the activity a participant should be able to:

• Describe the changes in left ventricular (LV) volume after correction of valve regurgitation.
• Relate severity of mitral and tricuspid valve regurgitation to late patient survival and functional outcome.
• Explain how volumetric assessment helps in decision making for intervention in patients with valvular regurgitation and cardiomyopathy.

Disclosures:

Hartzell V. Schaff, MD, has nothing to disclose relevant to this program.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

The Role of Coronary Revascularization for Chronic Coronary Syndrome

Ajay Kirtane, MD, SM, FSCAI

Professor of Medicine
Columbia University Irving Medical Center (CUMC)
Director and Chief Academic Officer
Columbia Interventional Cardiovascular Care Center
New York Presbyterian (NYP) Hospital
Seymour, Paul and Gloria Milstein Division of Cardiology
Columbia University Department of Medicine
New York, New York

Overview:

Dr. Kirtane will review the clinical evidence and data regarding the role of coronary revascularization for chronic coronary syndromes, focusing upon both anginal symptom relief as well as the prognostic impact of revascularization. A fundamental focus of the talk is to espouse a clinically rational approach to patients with chronic coronary syndrome: one that emphasizes disease-modifying medical therapy for all patients and carefully selecting higher-risk patients for coronary revascularization.

Objectives:

At the conclusion of the activity a participant should be able to:

• Describe the goals of therapy for patients with chronic coronary syndrome.
• Explain the rationale behind revascularization of patients with chronic coronary syndrome.
• Enumerate how the application of evidence-based therapies in the clinical practice of managing coronary artery disease varies based upon patient and clinical characteristics (Risk).

Disclosures:

Ajay Kirtane, MD, received grants from Medtronic, Boston Scientific, Neurotronic, Biotronik and Chiesi. He received travel funding from Amgen, Medtronic and Biotronik.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CME credits must be claimed within 24 hours after a live conference.

Visceral Organ Doppler: A Portal to Volume Status

Mourad H. Senussi, MD, MS

Academic Professional Staff
The Texas Heart Institute
Assistant Professor
Medicine – Cardiology & Critical Care Medicine
Baylor College of Medicine
Medical Director of CICU
St. Luke’s Health – Baylor St. Luke’s Medical Center
Houston, Texas

Overview:

Dr. Senussi will discuss the use of hepatic, portal, and intrarenal venous Doppler waveforms in assessing volume status.

Objectives:

At the conclusion of the activity a participant should be able to:

• Explain the pitfalls of traditional methods of assessing volume status.
• Define hepatic, portal, and intrarenal Venous Doppler waveforms to augment clinical decision making.
• Assess future directions in the utility of visceral Doppler waveform interpretation in complex cardiac patients.

Disclosures:

Mourad Senussi, MD, MS, has nothing to disclose relevant to this program.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Transcatheter Pulmonary Valve Replacement: Keeping the Right Heart Right

Dhaval Parekh, MD

Teaching Staff, The Texas Heart Institute
Section Editor, Congenital Heart Disease, The Texas Heart Institute Journal
Senior Faculty, Medicine – Cardiology
Baylor College of Medicine
Associate Director, Adult Congenital Heart Disease Program
Pediatrics
Pediatric Cardiology/Adult Congenital Heart Disease
Texas Children’s Hospital
St. Luke’s Health – Baylor St. Luke’s Medical Center
Houston, Texas

Overview:

Transcatheter Pulmonary Valve Replacement (TPVR) is revolutionizing the management of right ventricular outflow tract (RVOT) dysfunction, offering a less invasive alternative to open-heart surgery. Dr. Parekh will explore the evolution of TPVR, its impact on preserving right heart function, and latest advancements in valve technology. He will also discuss patient selection, procedural challenges, and long-term outcomes.

Objectives:

At the conclusion of the activity a participant should be able to:

• Explain the role of TPVR in mitigating right heart dysfunction.
• Recognize ideal candidates with procedural considerations, challenges and complications.
• Discuss evolutionary milestones and emerging technologies for TPVR.

Disclosures:

Dhaval Parekh, MD, is a consultant for Abbott, Gore and Angiodynamics.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CME credits must be claimed within 24 hours after a live conference.

21st Century Challenges for the General Cardiologist

Patrick T. O’Gara, MD, MACC, FAHA, FESC

Watkins Family Distinguished Chair in Cardiology
Professor, Harvard Medical School
Cardiovascular Medicine
Director of Strategic Planning, Cardiovascular Division
Brigham and Women’s Hospital
Boston, Massachusetts

Overview:

This presentation will initially reflect on the career pathway for a general cardiologist and then dive into several areas in the field of valvular heart disease in which the cardiologist will need to become more facile with the technological and biological underpinnings of disease.

Objectives:

At the conclusion of the activity a participant should be able to:

• Demonstrate awareness of the impact of genetics and artificial intelligence on clinical care.
• Identify recent insights into the pathogenesis of aortic and mitral valve disease.
• Determine key attributes needed for navigating the clinical landscape.

Disclosures:

Patrick O’Gara, MD, has nothing to disclose relevant to this program.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Cardiac Amyloidosis

Mathew Maurer, MD, FACC

Arnold and Arlene Goldstein Professor of Cardiology
Director, Clinical Cardiovascular Research Laboratory for the Elderly
CUIMC/Vivian & Seymour Milstein Family Heart Center
Columbia University Irving Medical Center
Vagelos College of Physicians & Surgeons
Director, Cardiac Amyloidosis Program
Advanced Cardiac Care Center
NewYork Presbyterian Hospital – Columbia Campus
New York, New York

Overview:

This presentation will describe the evolution of cardiac amyloidosis from a rare, underdiagnosed and untreatable condition to increasingly and easily recognized and treatable.

Objectives:

At the conclusion of the activity a participant should be able to:

• Identify the phenotype of cardiac amyloidosis in order to facilitate early diagnosis.
• Distinguish underlying causes of cardiac amyloidosis given differences in prevalence, genetics, prognosis and treatment.
• Enumerate emerging strategies to address transthyretin (TTR) cardiac amyloidosis.

Disclosures:

Mathew Maurer, MD, receives grants from Attralus. He receives grants from and is a consultant for Pfizer, Intellia, Ionis, Astra-Zeneca, BridgeBio, Alnylam, and Novo Nordisk.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CME credits must be claimed within 24 hours after a live conference.

Evolution of Complex Endovascular Aortic Repair

Gustavo S. Oderich, MD, FACS

Professor of Surgery
Chief of Vascular Surgery and Endovascular Therapy
Director, Aortic Center
Baylor College of Medicine
St. Luke’s Health – Baylor St. Luke’s Medical Center
Houston, Texas

Overview:

Dr. Oderich will review the evolution of endovascular repair to treat complex aortic aneurysms, including indications, technical pitfalls and outcomes of fenestrated-branched endografts to treat thoracoabdominal aortic aneurysms.

Objectives:

At the conclusion of the activity a participant should be able to:

• Explain the indications and anatomical requirements for complex endovascular repair.
• Review technical aspects of the procedure.
• Explain clinical outcomes as compared to alternative options of open surgical repair.

Disclosures:

Gustavo S. Oderich, MD, is a consultant and on the advisory board for Cook Medical, Inc., WL Gore, GE Healthcare, and Centerline Biomedical.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

From Intervention to Prevention: Improving PCI Outcomes

Roxana Mehran, MD, FACC, FACP, FCCP, FESC, FAHA, FSCAI

Professor of Medicine, Cardiology and Population Health Science and Policy
Mount Sinai Endowed Professor in Cardiovascular Clinical Research and Outcomes
Director, Interventional Cardiovascular Research and Clinical Trials
Zena and Michael A. Wiener Cardiovascular Institute
Director, Women’s Heart and Vascular Center at Mount Sinai Fuster Heart
Icahn School of Medicine at Mount Sinai
Mount Sinai Health System
New York, New York

Overview:

Dr. Roxana Mehran will explore strategies to optimize coronary artery disease (CAD) management by integrating advanced technologies, pharmacological therapies, and risk stratification approaches. The lecture highlights the role of cutting-edge techniques to refine percutaneous coronary intervention (PCI), discusses the importance of cardiometabolic and anti-inflammatory therapies in cardiovascular prevention and examines the latest evidence on risk stratification. The ultimate goal is to bridge the gap between intervention and prevention, ensuring improved long-term outcomes for CAD patients.

Objectives:

At the conclusion of the activity a participant should be able to:

• Identify the role of new technologies, including advanced imaging modalities, in enhancing procedural precision, assessing lesion characteristics, and guiding PCI to improve outcomes.
• Explore the impact of cardiometabolic drugs and inflammation-targeting therapies in reducing cardiovascular risk and improving long-term outcomes for CAD patients.
• Review strategies to tailor antithrombotic regimens based on patient-specific risk profiles to achieve an optimal balance between minimizing bleeding complications and preventing thrombotic events.

Disclosures:

Roxana Mehran, MD, has received grants from Janssen, Novartis and Novo Nordisk.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Hypertrophic Cardiomyopathy in 2025: A Not Uncommon, Treatable, Genetic Disease, with Low Mortality

Martin S. Maron, MD

Assistant Professor of Medicine
Division of Cardiology
Tufts University School of Medicine
Medical Director, Hypertrophic Cardiomyopathy Center
Lahey Hospital & Medical Center
Beth Israel Lahey Health
Burlington, Massachusetts

Overview:

Dr. Maron will provide an overview of the progress in the diagnosis, management and treatment strategies that have evolved over the last 60 years in hypertrophic cardiomyopathy (HCM). This will include the evolution of a mature risk stratification strategy and integration of implantable cardioverter defibrillators (ICDs) to HCM that have lowered sudden cardiac death event rates, as well as data supporting a low threshold for anticoagulation therapy in the setting of atrial fibrillation. In addition, we will discuss emergence of novel drug therapy with myosin inhibitors and their role in the current treatment strategy of symptomatic obstructive HCM patients.

Objectives:

At the conclusion of the activity a participant should be able to:

• Clarify current risk stratification strategy to identify high risk HCM patients for ICD.
• Explain the mechanism driving symptom limitation in obstructive HCM.
• Review the current role of drug therapies and invasive options for heart failure in setting of obstructive and nonobstructive HCM.

Disclosures:

Martin Maron, MD, is a DSMB member for Edgewise. He chairs and serves as a steering committee member for Cytokinetics and a consultant for Imbria.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CME credits must be claimed within 24 hours after a live conference.

BC Transfusion Thresholds in Cardiac Patients: How Low Can We Go?

Jeffrey L. Carson, MD, MACP

Provost, New Brunswick, Rutgers Biomedical Health Sciences
Distinguished Professor of Medicine
Richard C. Reynolds, MD, Chair in General Internal Medicine
Robert Wood Johnson Medical School
Rutgers Health
New Brunswick, New Jersey

Overview:

Dr. Carson will review adverse effects of transfusion, risk of anemia and clinical trial data evaluating transfusion thresholds in patients with and without cardiovascular disease.

Objectives:

At the conclusion of the activity a participant should be able to:

• Articulate the safety of red blood cell (RBC) transfusions.
• Articulate the association between anemia, cardiovascular disease and mortality.
• Articulate the clinical trial evidence and latest guidelines on transfusion threshold in patients with and without cardiovascular disease.

Disclosures:

Jeffrey Carson, MD, chairs the DSMB for a trial and is a speaker for and receives honoraria from Cerus. He is a speaker for and receives honoraria from Bristol Myers Squibb.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

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Controversies in Coronary Revascularization and the Guidelines

Faisal Bakaeen, MD

Professor of Surgery
Cleveland Clinic Lerner College of Medicine
Sheikh Hamdan bin Rashid Al Maktoum Distinguished Chair in Thoracic and Cardiovascular Surgery
Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute
Cleveland Clinic
Cleveland, Ohio

Contributions of Pathobiological and Translational Science To Progress in Counteracting Ischemic Heart Disease: Quo Vadis? In the Contemporary Healthcare Environment

L. Maximilian Buja, MD

Academic Professional Staff
Chief, Cardiovascular Pathology Research
The Texas Heart Institute
Dean Emeritus
Professor of Pathology
McGovern Medical School
The University of Texas Health Science Center at Houston (UTHealth Houston)
Houston, Texas

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Stanley Hazen, MD, PhD

Chair, Department of Cardiovascular & Metabolic Sciences
The Jan Bleeksma Chair in Vascular Cell Biology and Atherosclerosis
Director, Center for Cardiovascular Diagnostics & Prevention
Director, Center for Microbiome & Human Health
Lerner Research Institute
Co-Section Head, Preventive Cardiology & Rehabilitation
Heart, Vascular & Thoracic Institute
Cleveland Clinic
Cleveland, Ohio

Joseph G. Rogers, MD

President and Chief Executive Officer
O’Quinn/Willerson Endowed Chair
The Texas Heart Institute
The Texas Heart Institute Center for Cardiovascular Care
Faculty, Medicine
Baylor College of Medicine
St. Luke’s Health – Baylor St. Luke’s Medical Center
Houston, Texas