John Elrod, PhD
Director of the Cardiovascular Research Center in the Lewis Katz School of Medicine at Temple University
Overview:
We recently reported that glutaminolysis is essential for the epigenetic changes permissive to activation of the myofibroblast differentiation program and cardiac fibrosis. In fact, targeting these pathways is sufficient to reverse fibrosis in models of heart failure. These findings implicate metabolic remodeling as a critical feature of myofibroblast formation and persistence in the diseased heart. This presentation will highlight metabolite-dependent epigenetic signaling, new data implicating paracellular metabolic crosstalk as prominent mechanism in myofibroblast formation, and novel therapeutic targets in cardiac fibrosis and heart failure.
Objectives:
At the conclusion of the activity a participant should be able to:
- Differentiate the role of fibroblast fate in the cardiac fibrotic response.
- Define the molecular pathways underlying myofibroblast formation and persistence.
- Summarize the basic metabolic underpinnings of fibroblast ECM deposition and function in the failing heart.
Disclosures:
John Elrod, PhD is a Paid consultant and SRA unrelated to current work for Mitobridge Inc., an Astellas Company. He is also an Consultant on projects unrelated to current work for Janssen, J&J.
The Planning Committee has nothing to disclose relevant to this program.
The THI CME Staff has nothing to disclose relevant to this program.
The Program Reviewers has nothing to disclose relevant to this program.
Accreditation
Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation
Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
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Accreditation and Credit Designation
Texas Heart Institute is accredited by the Accreditation Council or Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Texas Heart Institute designates this live activity for a maximum of 1.0 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
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