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Jun Wang, MD, PhD

Cardiovascular disease is the leading cause of death worldwide. The research interest of my lab is to understand the molecular mechanisms underlying the cardiac development and disease including congenital cardiac defects, cardiomyopathy, heart failure, and regeneration. Show full bio

We use molecular, biochemical, and genetical approaches to investigate the Yap signaling and posttranslational modifications such as SUMO conjugation for heart development and pathogenesis. Our goal is to provide rationale for targeting these signaling/pathways as therapeutic strategies to combat heart diseases

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Texas Heart Institute Positions

Education

  • Graduate:

    Shanghai 2nd Medical University

  • Postgraduate:

    University of Montreal
    Clinical Research Institute of Montreal

  • Medical School:

    Wen Zhou Medical College

Publications

Sun, F., Wei, Y., Liu, Z. et al. (2022). Acylglycerol kinase promotes ovarian cancer progression and regulates mitochondria function by interacting with ribosomal protein L39. J Exp Clin Cancer Res 41, 238. https://doi.org/10.1186/s13046-022-02448-5.
Zhang, Y., Beketaev, I., Ma, Y. et al. (2022). Sumoylation-deficient phosphoglycerate mutase 2 impairs myogenic differentiation. Front Cell Dev Biol 10, 1052363. https://doi.org/10.3389/fcell.2022.1052363.
Tang, L., Hill, M. C., Wang, J. et al. (2020). Predicting unrecognized enhancer-mediated genome topology by an ensemble machine learning model. Genome Res 30, 1835–1845. https://doi.org/10.1101/gr.264606.120.
Heallen, T. R., Kadow, Z. A., Wang, J. et al. (2020). Determinants of cardiac growth and size. Cold Spring Harb Perspect Biol 12. https://doi.org/10.1101/cshperspect.a037150.
Zhang, Y., Beketaev, I., Segura, A. M. et al. (2020). Contribution of increased expression of Yin Yang 2 to development of cardiomyopathy. Front Mol Biosci 7, 35. https://doi.org/10.3389/fmolb.2020.00035.
Deshmukh, V., Wang, J. and Martin, J. F. (2019). Leading progress in heart regeneration and repair. Curr Opin Cell Biol 61, 79–85. https://doi.org/10.1016/j.ceb.2019.07.005.
Xiao, Y., Hill, M. C., Li, L. et al. (2019). Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis. Genes Dev 33, 1491–1505. https://doi.org/10.1101/gad.329763.119.
Heallen, T. R., Kadow, Z. A., Kim, J. H. et al. (2019). Stimulating cardiogenesis as a treatment for heart failure. Circ Res 124, 1647–1657. https://doi.org/10.1161/CIRCRESAHA.118.313573.
Liang, C., Chen, X., Gao, X. et al. (2019). Spectrum of thalassemia mutations in fetuses of Han and Li ethinicities in Hainan province, China. Asian Pac J Trop Med 12, 537. https://doi.org/10.4103/1995-7645.272483.
Li, J., Yue, G., Ma, W. et al. (2018). Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure. Circ Heart Fail 11, e004917. https://doi.org/10.1161/CIRCHEARTFAILURE.118.004917.