Todd R. Heallen, PhD
Texas Heart Institute Positions
- Assistant Research Investigator, Cardiomyocyte Renewal Laboratory
Interests
- Cardiac Regeneration
Education
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Undergraduate:
Texas A&M University
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Postgraduate:
UTHSCH-GSBS
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Fellowships:
Texas A&M IBT; Baylor College of Medicine
Academic & Clinical Affiliations
- Baylor College of Medicine
Honors, Awards and Memberships
- American Heart Association
Publications
Liu, S., Tang, L., Zhao, X. et al. (2021). Yap promotes noncanonical Wnt signals from cardiomyocytes for heart regeneration. Circ Res 129, 782–797. https://doi.org/10.1161/CIRCRESAHA.121.318966.
Liu, S., Li, K., Wagner Florencio, L. et al. (2021). Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci Transl Med 13, eabd6892. https://doi.org/10.1126/scitranslmed.abd6892.
Heallen, T. R., Kadow, Z. A., Wang, J. et al. (2020). Determinants of cardiac growth and size. Cold Spring Harb Perspect Biol 12. https://doi.org/10.1101/cshperspect.a037150.
Heallen, T. R., Kadow, Z. A., Kim, J. H. et al. (2019). Stimulating cardiogenesis as a treatment for heart failure. Circ Res 124, 1647–1657. https://doi.org/10.1161/CIRCRESAHA.118.313573.
Monroe, T. O., Hill, M. C., Morikawa, Y. et al. (2019). YAP partially reprograms chromatin accessibility to directly induce adult cardiogenesis in vivo. Dev Cell 48, 765-779.e7. https://doi.org/10.1016/j.devcel.2019.01.017.
Wang, J., Liu, S., Heallen, T. et al. (2018). The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nat Rev Cardiol 15, 672–684. https://doi.org/10.1038/s41569-018-0063-3.
Heallen, T. R. and Martin, J. F. (2018). Heart repair via cardiomyocyte-secreted vesicles. Nat Biomed Eng 2, 271–272. https://doi.org/10.1038/s41551-018-0239-5.
Leach, J. P., Heallen, T., Zhang, M. et al. (2017). Hippo pathway deficiency reverses systolic heart failure after infarction. Nature 550, 260–264. https://doi.org/10.1038/nature24045.
Morikawa, Y., Heallen, T., Leach, J. et al. (2017). Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. Nature 547, 227–231. https://doi.org/10.1038/nature22979.
Tao, G., Kahr, P. C., Morikawa, Y. et al. (2016). Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature 534, 119–123. https://doi.org/10.1038/nature17959.
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