CATO (NCT06145035)

Single or repeated intravenous administration of umbiliCal cord mesenchymal sTrOmal cells in ischemic cardiomyopathy.

PI: Emerson Perin, MD, PhD

Sponsor: University of Louisville

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A Phase IIA, randomized, double blind, placebo-controlled study of single versus repeated intravenous administration of umbilical cord derived mesenchymal stromal cells (UC-MSCs) in patients with ischemic cardiomyopathy.

Eligibility Requirements

1. Greater or equal to 21 and less than 85 years of age.
2. Have documented coronary artery disease with evidence of myocardial injury, left ventricular dysfunction, and clinical evidence of heart failure.
3. Have an ejection fraction less than or equal to 40% by MRI.
4. Have NYHA class I, II, or III symptoms of heart failure.